Welcome to Caspase cleavage database

Caspases (cysteine-dependent aspartate-directed proteases) are intracellular proteases that are best known for their function in apoptosis (programmed cell death), necrosis, and inflammation.

Caspases are known to have restricted substrate specificity for an aspartic acid residue (D) at position P1 of the target substrate except few substrates, which has glutamic acid residue (E) at position P1.

To date, 520 human proteins were experimentally verified as caspase substrates in casbah database. In which 502 proteins are non secreted protein and 18 are secreted proteins. Based on known caspase substrates and their cleavages, we made machine learning prediction model and predicted caspase cleavages for all human reviewed protein from uniprot and compiled in form of CaspDB database.

Database statistics
Human uniprot reviewed protein : 20235
Secreted protein : 3368
Non secreted protein : 16867
When referring to CaspDB, please cite:

Kumar S, van Raam BJ, Salvesen GS, Cieplak P(2014)
Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates.
PLoS One. 2014 Oct 17;9(10):e110539